Beyond testosterone cypionate: evidence behind the use of nandrolone in male health and wellness PMC
Indeed, the most established management paradigm for the treatment of alopecia in the male is finasteride (24). First approved in 1992 in the treatment of benign prostatic hypertrophy, finasteride was approved for the treatment of alopecia in 1997 at a dose of 1 mg daily (propecia®) (24). In men on TST, finasteride at 1 mg is used as a means of preventing the excess exogenously administered testosterone from converting to DHT. By decreasing the amount of DHT, less is available to act on the hair follicles stabilizing the amount of hair loss. Although previous studies verified the association between AAS exposure and high blood pressure, the molecular mechanisms involved in blood pressure increase due to AASs are not fully understood.
- The compound is famous not only among adults, but also adolescents because of its anabolic, muscle-building properties [10,11,12,13].
- Due, in part, to these adverse effects, and the development of newer and more effective therapies to treat osteoperosis (i.e., bisphosphonates), nandrolone never gained traction as an effective clinical adjunct for this indication.
- Be aware that some people like to underdose or scam people with this compound, so buyer beware.
- Despite this, nandrolone’s stimulatory effects on bone and soft tissues became the basis upon which some researchers suggested its use in anemia and muscle wasting secondary to hemodialysis and/or HIV (8,9).
Nandrolone phenpropionate
Since that time numerous versions of Nandrolone have hit the shelves, but Deca Durabolin has remained the most well known; in fact, it’s not uncommon for all Nandrolone versions to be referred to as Deca even if they aren’t. Your healthcare provider will take a complete medical history before prescribing nandrolone. Even when taken at the appropriate doses, nandrolone can cause heart failure and liver damage. It can cause a child’s bones to stop growing before they reach their full height. Your healthcare provider will regularly monitor your child’s bones if they take nandrolone.
Deca Durabolin vs EQ (Equipoise)
Unfortunately, hyperproteic diets are often not balanced and excessive proteins are eliminated through urine or converted into fat [39,41]. Even though legitimate pharmaceutical grade AASs can be purchased on the black market via several routes, physician supervision of usage is usually lacking, making a legitimate pharmaceutical product potentially dangerous for uninformed users. Since buying and using AASs (without a medical prescription) is a criminal act in many countries, the AAS user is often reluctant to seek advice from a physician when health Omnitrop bodybuilding issues arise.
Why is nandrolone banned?
The absorbance of the formazan at 490 nm was measured directly using the Plate Reader (Das srl, Italy) with a reference filter at 630 nm. The theory underlying the possible use of nandrolone in the context of alopecia results from the fact that it does not convert to DHT but instead gets transformed into 5α-dihydro-19-nortestosterone, a molecularly distinct compound (15,25). It is thus possible that in hypogonadal males nandrolone, in addition to or in replacement for testosterone, could alleviate concerns for the development of androgenic alopecia.
Indeed, treatment of HepG2 with ND under our experimental conditions did not result in any change neither of the IGFR1 expression or IGF-1 release or Akt-signaling activation (data not shown). Nandrolone is a testosterone analogue with anabolic properties commonly abused worldwide, recently utilized also as therapeutic agent in chronic diseases, cancer included. Here we investigated the impact of nandrolone on the metabolic phenotype in HepG2 cell line.